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human embryonic lung fibroblast cell line mrc 5  (ATCC)


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    ATCC human embryonic lung fibroblast cell line mrc 5
    Human Embryonic Lung Fibroblast Cell Line Mrc 5, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 5423 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+lung+fibroblast+mrc+5+cell+line/MRC-5/pm42271325-65-0-8
    Average 99 stars, based on 5423 article reviews
    human embryonic lung fibroblast cell line mrc 5 - by Bioz Stars, 2026-09
    99/100 stars

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    Related Articles

    Concentration Assay:

    Article Title: Evaluation of the cytotoxicity and antibacterial activity of nano-selenium prepared via gamma irradiation against cancer cell lines and bacterial species
    Article Snippet: .. The effects of the tested compounds and cisplatin reference drug were measured on normal human lung fibroblast (MRC-5) cell line (obtained from the American Type Culture Collection, ATCC, Rockville, MD) as mentioned previously to produce a dose–response curve and to calculate the 50% cytotoxic concentration (CC50) using GraphPad Prism software. ..

    Article Title: Synthesis, Biological Evaluation, and Molecular Docking of Novel Azolylhydrazonothiazoles as Potential Anticancer Agents
    Article Snippet: .. To establish a dose–response curve and determine the 50% cytotoxic concentration (CC 50 ) of newly synthesized compounds and the reference drug doxorubicin, a normal human lung fibroblast (MRC-5) cell line procured from the American Type Culture Collection in Rockville, MD was utilized. .. GraphPad Prism software was utilized to perform the aforementioned calculations.

    Software:

    Article Title: Evaluation of the cytotoxicity and antibacterial activity of nano-selenium prepared via gamma irradiation against cancer cell lines and bacterial species
    Article Snippet: .. The effects of the tested compounds and cisplatin reference drug were measured on normal human lung fibroblast (MRC-5) cell line (obtained from the American Type Culture Collection, ATCC, Rockville, MD) as mentioned previously to produce a dose–response curve and to calculate the 50% cytotoxic concentration (CC50) using GraphPad Prism software. ..

    Synthesized:

    Article Title: Synthesis, Biological Evaluation, and Molecular Docking of Novel Azolylhydrazonothiazoles as Potential Anticancer Agents
    Article Snippet: .. To establish a dose–response curve and determine the 50% cytotoxic concentration (CC 50 ) of newly synthesized compounds and the reference drug doxorubicin, a normal human lung fibroblast (MRC-5) cell line procured from the American Type Culture Collection in Rockville, MD was utilized. .. GraphPad Prism software was utilized to perform the aforementioned calculations.

    Derivative Assay:

    Article Title: A 3D Organotypic Human Bronchial Model Reveals Persistent Infection and Modulated Inflammatory Response when Exposed to Brucella abortus
    Article Snippet: The 16HBE14o- human bronchial epithelial cell line (kindly provided by Dr. Dieter Gruenert), established from normal bronchial epithelium [ ], was routinely grown in fibronectin/collagen/BSA-coated flasks in minimal essential medium (MEM; Gibco, Thermo Fisher Scientific, Waltham, MA, USA) supplemented with 10% fetal calf serum (FCS; Natocor, Argentina), 2 mM L-glutamine, 100 U/mL penicillin, and 100 mg/mL streptomycin (all from Gibco, Thermo Fisher Scientific, Waltham, MA, USA). .. The human lung fibroblast MRC-5 cell line (ATCC CCL-171), which was derived from normal lung tissue of a 14-week-old male fetus, was maintained in supplemented MEM. ..

    Article Title: A 3D Organotypic Human Bronchial Model Reveals Persistent Infection and Modulated Inflammatory Response when Exposed to Brucella abortus
    Article Snippet: The 16HBE14o- human bronchial epithelial cell line (kindly provided by Dr. Dieter Gruenert), established from normal bronchial epithelium [25], was routinely grown in fibronectin/collagen/BSA-coated flasks in minimal essential medium (MEM; Gibco, Thermo Fisher Scientific, Waltham, MA, USA) supplemented with 10% fetal calf serum (FCS; Natocor, Argentina), 2 mM L-glutamine, 100 U/mL penicillin, and 100 mg/mL streptomycin (all from Gibco, Thermo Fisher Scientific, Waltham, MA, USA). .. The human lung fibroblast MRC-5 cell line (ATCC CCL-171), which was derived from normal lung tissue of a 14-week-old male fetus, was maintained in supplemented MEM. ..

    Cell Culture:

    Article Title: LncRNA HOXA11-AS promotes idiopathic pulmonary fibrosis progression via sponging miR-148a-3p and regulating SMAD2.
    Article Snippet: .. Cell culture and transfection The human alveolar epithelial cell line A549 (ATCC) and the human lung fibroblast MRC-5 cell line (BeNa Culture) were cultured in Dulbecco's Modified Eagle's Medium (DMEM, Gibco), supplemented with 10% fetal bovine serum (FBS) (Thermo Fisher Scientific), penicillin, and streptomycin, and maintained in a humidified incubator at 37 °C with 5% ..

    Transfection:

    Article Title: LncRNA HOXA11-AS promotes idiopathic pulmonary fibrosis progression via sponging miR-148a-3p and regulating SMAD2.
    Article Snippet: .. Cell culture and transfection The human alveolar epithelial cell line A549 (ATCC) and the human lung fibroblast MRC-5 cell line (BeNa Culture) were cultured in Dulbecco's Modified Eagle's Medium (DMEM, Gibco), supplemented with 10% fetal bovine serum (FBS) (Thermo Fisher Scientific), penicillin, and streptomycin, and maintained in a humidified incubator at 37 °C with 5% ..

    Modification:

    Article Title: LncRNA HOXA11-AS promotes idiopathic pulmonary fibrosis progression via sponging miR-148a-3p and regulating SMAD2.
    Article Snippet: .. Cell culture and transfection The human alveolar epithelial cell line A549 (ATCC) and the human lung fibroblast MRC-5 cell line (BeNa Culture) were cultured in Dulbecco's Modified Eagle's Medium (DMEM, Gibco), supplemented with 10% fetal bovine serum (FBS) (Thermo Fisher Scientific), penicillin, and streptomycin, and maintained in a humidified incubator at 37 °C with 5% ..



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    human embryonic lung fibroblast cell line mrc 5  (ATCC)
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    adherent human lung fibroblast cell line mrc 5  (ATCC)
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    ATCC adherent human lung fibroblast cell line mrc 5
    (A) Hierarchical clustering dendrograms of FBS conditions based on differential gene expression profiles <t>in</t> <t>MRC-5</t> (left), Jurkat (middle), and THP-1 (right) cells. Clustering was performed using the number of differentially expressed genes (DEGs; |log2FC| > 0.6, adjusted p-value < 0.05) as a distance metric. Horizontal red lines indicate the clustering threshold of 100 DEGs, defining distinct FBS clusters. MRC-5 and THP-1 cells show 4 distinct clusters, while Jurkat cells display 5 clusters, revealing cell type-specific responses to FBS alternatives. (B) Module size distributions from WGCNA for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Bar colors represent distinct co-expression modules identified using signed networks with Pearson correlation (soft-thresholding power selected to achieve scale-free topology R ≥ 0.8; minimum module size = 30 genes; merge cut height = 0.25). MRC-5 cells: 7 modules (turquoise: 4,728 genes; blue: 3,580; brown: 2,417; grey: 936; yellow: 634; green: 447; red: 234). Jurkat cells: 7 modules (turquoise: 4,234; blue: 3,635; grey: 2,289; brown: 1,464; yellow: 660; green: 240; red: 204). THP-1 cells: 5 modules (turquoise: 4,201; blue: 4,16; grey: 2,478; brown: 2,184; yellow: 434). (C) Module-trait relationship heatmaps showing Pearson correlations between module eigengenes and FBS cluster assignments for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Each cell displays the correlation coefficient (color scale: blue = -0.5, white = 0, red = 0.5) and corresponding p-value. Significant correlations (p < 0.05, calculated using corPvalueStudent) indicate modules with expression patterns specifically associated with FBS clusters. Notable associations include: MRC-5 turquoise module with Cluster 1 (r = - 0.45, p = 3.22×10 ); Jurkat red module with Cluster 2 (r = 0.76, p = 1.38×10 ); THP-1 yellow module with Cluster 1 (r = 0.65, p = 2.54×10 8).
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    (A) Hierarchical clustering dendrograms of FBS conditions based on differential gene expression profiles in MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Clustering was performed using the number of differentially expressed genes (DEGs; |log2FC| > 0.6, adjusted p-value < 0.05) as a distance metric. Horizontal red lines indicate the clustering threshold of 100 DEGs, defining distinct FBS clusters. MRC-5 and THP-1 cells show 4 distinct clusters, while Jurkat cells display 5 clusters, revealing cell type-specific responses to FBS alternatives. (B) Module size distributions from WGCNA for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Bar colors represent distinct co-expression modules identified using signed networks with Pearson correlation (soft-thresholding power selected to achieve scale-free topology R ≥ 0.8; minimum module size = 30 genes; merge cut height = 0.25). MRC-5 cells: 7 modules (turquoise: 4,728 genes; blue: 3,580; brown: 2,417; grey: 936; yellow: 634; green: 447; red: 234). Jurkat cells: 7 modules (turquoise: 4,234; blue: 3,635; grey: 2,289; brown: 1,464; yellow: 660; green: 240; red: 204). THP-1 cells: 5 modules (turquoise: 4,201; blue: 4,16; grey: 2,478; brown: 2,184; yellow: 434). (C) Module-trait relationship heatmaps showing Pearson correlations between module eigengenes and FBS cluster assignments for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Each cell displays the correlation coefficient (color scale: blue = -0.5, white = 0, red = 0.5) and corresponding p-value. Significant correlations (p < 0.05, calculated using corPvalueStudent) indicate modules with expression patterns specifically associated with FBS clusters. Notable associations include: MRC-5 turquoise module with Cluster 1 (r = - 0.45, p = 3.22×10 ); Jurkat red module with Cluster 2 (r = 0.76, p = 1.38×10 ); THP-1 yellow module with Cluster 1 (r = 0.65, p = 2.54×10 8).

    Journal: bioRxiv

    Article Title: Towards molecular-based functional classification of fetal bovine serum

    doi: 10.64898/2026.03.16.712020

    Figure Lengend Snippet: (A) Hierarchical clustering dendrograms of FBS conditions based on differential gene expression profiles in MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Clustering was performed using the number of differentially expressed genes (DEGs; |log2FC| > 0.6, adjusted p-value < 0.05) as a distance metric. Horizontal red lines indicate the clustering threshold of 100 DEGs, defining distinct FBS clusters. MRC-5 and THP-1 cells show 4 distinct clusters, while Jurkat cells display 5 clusters, revealing cell type-specific responses to FBS alternatives. (B) Module size distributions from WGCNA for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Bar colors represent distinct co-expression modules identified using signed networks with Pearson correlation (soft-thresholding power selected to achieve scale-free topology R ≥ 0.8; minimum module size = 30 genes; merge cut height = 0.25). MRC-5 cells: 7 modules (turquoise: 4,728 genes; blue: 3,580; brown: 2,417; grey: 936; yellow: 634; green: 447; red: 234). Jurkat cells: 7 modules (turquoise: 4,234; blue: 3,635; grey: 2,289; brown: 1,464; yellow: 660; green: 240; red: 204). THP-1 cells: 5 modules (turquoise: 4,201; blue: 4,16; grey: 2,478; brown: 2,184; yellow: 434). (C) Module-trait relationship heatmaps showing Pearson correlations between module eigengenes and FBS cluster assignments for MRC-5 (left), Jurkat (middle), and THP-1 (right) cells. Each cell displays the correlation coefficient (color scale: blue = -0.5, white = 0, red = 0.5) and corresponding p-value. Significant correlations (p < 0.05, calculated using corPvalueStudent) indicate modules with expression patterns specifically associated with FBS clusters. Notable associations include: MRC-5 turquoise module with Cluster 1 (r = - 0.45, p = 3.22×10 ); Jurkat red module with Cluster 2 (r = 0.76, p = 1.38×10 ); THP-1 yellow module with Cluster 1 (r = 0.65, p = 2.54×10 8).

    Article Snippet: The adherent human lung fibroblast cell line MRC-5 (CCL-171), the suspension human monocytic cell line THP-1 (TIB-202), and the human acute T-cell leukemic cell line Jurkat Clone E6-1 (TIB-152) were purchased from American Type Culture Collection (ATCC, USA).

    Techniques: Gene Expression, Expressing